This issue of Psychiatric Clinics, guest-edited by Drs. Robert Wisner-Carlson, Thomas Flis, Scott Pekrul, and Robert Schloesser will discuss a number of important topics addressing Autism Disorders Across the lifespan. This issue is one of four each year selected by our series consulting editor, Dr. Harsh Trivedi of Sheppard Pratt Health System. Part I of this issue published previously. Articles in this issue include: Bipolar Disorder and Psychosis in Autism; Catatonia in Patients with Autism Spectrum Disorder; Use of Electroconvulsive Therapy in Autism; Autism Spectrum Disorder and Substance Use Disorder: A Dual Diagnosis Hiding in Plain Sight; Seizures and Epilepsy in Autism Spectrum Disorder; Gastrointestinal Issues and Autism Spectrum Disorder; The Impact of Applied Behavior Analysis to Address Mealtime Behaviors of Concern Among Individuals with Autism Spectrum Disorder; Assessment and Treatment of Emotion Regulation Impairment in Autism Spectrum Disorder Across the Life Span: Current State of the Science and Future Directions; Sexuality and Gender Issues in Individuals with Autism Spectrum Disorder; and Facial Expression Production and Recognition in Autism Spectrum Disorders: A Shifting Landscape.