Justin Benson and Aaron Moorhead co-direct this US sci-fi horror starring Jamie Dornan and Anthony Mackie. New Orleans paramedics Dennis and Steve (Dornan and Mackie) discover a new drug called Synchronic is responsible for a series of mysterious deaths across the city. When Steve learns that he has an inoperable brain tumour, he attempts to rid the city of Synchronic but finds himself using it to search for Dennis's daughter, Brianna (Ally Ioannides), who has recently disappeared.