In this issue of Pediatric Clinics of North America, guest editors Drs. Paul Lipkin and Joshua Ewen, both of the Kennedy Krieger Institute and Johns Hopkins School of Medicine, bring their considerable expertise to the topic of Autism Spectrum Disorder. While pediatricians now have adopted screening and early identification of autism spectrum disorder into their practices, limited training has been provided around longer-term care throughout their childhood. This issue focuses on the newest information on the fundamental neuroscience and genetics of autism and the care needs of children with autism during middle childhood and adolescence. Contains 14 relevant, practice-oriented topics on the autism constellation and neurodiversity (including autism in adults); diagnosis of autism and its differential; psychopharmacology management of autism; autism in the schools and at home; evidence-based interventions in autism; mortality and autism: suicide and elopement; and more. Provides in-depth clinical reviews on autism spectrum disorder, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.