In this issue of Medical Clinics of North America, guest editor Dr. Jennifer A. Hanrahan brings her considerable expertise to the topic of Management of Severe Infections. Top experts cover how to diagnose and manage severe infections in the primary care setting, including Clostridioides difficile colitis and recurrent Clostridioides difficile, vertebral osteomyelitis and epidural abcess, prosthetic joint infections, measles, and more. Contains 13 relevant, practice-oriented topics including severe tuberculosis infections; severe STI: Mpox, neurosyphilis, TOA; bacterial meningitis; bacterial pneumonia; and more Provides in-depth clinical reviews on management of severe infections, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews