This issue of Veterinary Clinics: Exotic Animal Practice, guest edited by Dr. Shangzhe Xie, is focused on Herd/Flock Health and Medicine for the Exotic Animal Practitioner. This is one of three issues each year selected by the series consulting editor, Dr. Jörg Mayer. Article topics include: Principles of herd/flock health and medicine; Therapeutics in herd/flock medicine; Managing the health of captive flocks of birds; Managing disease outbreaks in captive flocks of birds; Managing the health of captive herds of exotic companion mammals; Managing disease outbreaks in captive herds of exotic companion mammals; Managing the health of captive groups of reptiles and amphibians; Prevention is Better Than Cure: an Overview of Disease Outbreak Management in Herptiles; Reproduction management of herds/flocks of exotic animals; and Disease prevention programs in herds/flocks of exotic animals