This issue of Veterinary Clinics of North America: Equine Practice focuses on Equine Sports Medicine and includes topics on: Lameness evaluation in the equine athlete; Diagnosis of soft tissue injury in the sport horse; Upper airway conditions affecting the equine athlete; Lower airway conditions affecting the equine athlete; Cardiac/Cardiovascular conditions affecting sport horses; Neck, back, and pelvic pain in sport horses; Neurologic conditions affecting the equine athlete; Metabolic diseases in the equine athlete; Muscle conditions affecting sport horses; Lyme disease in the sport horse; Management and rehabilitation of joint disease in sport horses; Regenerative medicine and rehabilitation for tendinous and ligamentous injuries in sport horses; and Chiropractic and manual therapies.