Epilepsy afflicts more than two million people in the United States and over 50 million people globally. This issue of Neurologic Clinics contains the following articles on this condition: Sudden Unexplained Death in Epilepsy; Approaches to Seizure Prediction; Localizing Seizure Onset; Concomitant Mood Disorders; Advances in the Genetics of Epilepsy; Psychogenic Nonepileptic Seizures; Selection of AEDs; Indentification of Refractory Epilepsy; Therapeutic Brain Stimulation in Epilepsy; AED Tertogneiticity; Hormonal Aspects of Epilepsy; Epilepsy and Radiosurgery; Epilepsy and Cognition; and Determinants of Quality of Life in Epilepsy.