In this issue of Rheumatic Disease Clinics, guest editors Drs. Jeffrey A. Sparks and Zachary S. Wallace bring their considerable expertise to the topic of COVID-19. Top experts cover key topics such as the impact of COVID-19 in patients with rheumatic diseases; vaccine immunogenicity and effectiveness in patients with rheumatic disease; long COVID burden in rheumatic disease; long COVID management strategies; COVID-19 impacts on autoimmunity and autoimmune disease; and more. Contains 11 relevant, practice-oriented topics including myalgia and fatigue after COVID-19; considerations for COVID-19 vaccination among B cell depleted patients; breakthrough infection after COVID-19 vaccination; interventions to Improve COVID-19 vaccine hesitancy; and more. Provides in-depth clinical reviews on COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.