This issue of Heart Failure Clinics, edited by Dr. Roberto Manfredini, will cover an array of topics related to Chronobiology and Cardiovascular Diseases. Topics include, but are not limited to Clock genes, metabolism and cardiovascular risk; Cardiac clocks and preclinical translation; Chronobiology of arterial blood pressure; Circadian periodicity of ischemic heart disease; Seasonal periodicity of ischemic heart disease and heart failure; Chronobiologic aspects of venous thromboembolism; Chronobiologic aspects of acute aortic diseases; Circaseptan periodicity of CV diseases; Gender and periodicity of CV disease; Chronopharmacology of CV drugs; Chronotherapy of Hypertension; and Chronoprevention of CV diseases.