The Handbook of Reliability, Maintenance, and System Safety through Mathematical Modeling discusses the many factors affect reliability and performance, including engineering design, materials, manufacturing, operations, maintenance, and many more. Reliability is one of the fundamental criteria in engineering systems design, with maintenance serving as a way to support reliability throughout a system’s life. Addressing these issues requires information, modeling, analysis and testing. Different techniques are proposed and implemented to help readers analyze various behavior measures (in terms of the functioning and performance) of systems.