Primatologist Davis (Dwayne Johnson) shares an unshakable bond with George, the extraordinarily intelligent silverback gorilla who has been in his care since he was young. When a greed-fuelled corporation's genetic experiment goes awry, George and other animals across the country are mutated into aggressive super-creatures who destroy everything in their path. In this adrenaline-filled ride, Davis tries to find an antidote, not only to halt a global catastrophe but also to save the fearsome creature who was once his friend.