In this issue of PET Clinics, guest editors Drs. Abass Alavi, Andrew B. Newberg, Poul Flemming Høilund-Carlsen, and Eric Guedj bring their considerable expertise to the topic of PET-CT-MRI in Central Nervous System Disorders with Emphasis on Dementias. Top experts in the field provide an overview of PET imaging in the most common dementias and brain diseases, such as Alzheimer’s and epilepsy. Specific articles also investigate normal brain aging, long COVID, brain trauma, and human experience and consciousness. Contains 12 relevant, practice-oriented topics including PET, CT, and MRI/fMRI in Alzheimer’s disease; brain PET imaging of movement disorders; the role of PET in depressive disorders; PET imaging for assessing brain function in normal aging; brain PET imaging of epilepsy; and more. Provides in-depth clinical reviews on PET-CT-MRI in CNS disorders with emphasis on dementias, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.