This book investigates the mechanisms that may stimulate or hamper the renewal of the regional industry structure. Recent years have witnessed a strong interest in, and need for, the modernization and upgrading of existing industries and the introduction of new industries. Informed by the evolutionary perspective this book argues that innovations within existing industry paths and the creation of new industries are strongly rooted in the established economic practice. Historically developed skills, existing industrial structure and regional and extra-regional networks form the basis for future regional growth. This volume consists of 11 chapters studying different aspects of regional industrial path development illustrated with cases from Norway, Sweden and Spain. The book also look into the role of policy for regional economic renewal, and argues that economic renewal is fostered by policies that incorporate both actor-based and system-based elements. Such policy mix will provide a vital push towards renewal and new path development. The chapters were originally published as a special issue in European Planning Studies.