This issue of Veterinary Clinics: Small Animal Practice, guest edited by Drs. Karl Maritato and Matthew Barnhart, focuses on Minimally Invasive Fracture Repair. Articles in this issue include, but are not limited to: Biomechanics of Fracture Fixation; Challenges in Minimally Invasive Fracture Repair; Minimally Invasive Osteosynthesis Fracture Reduction Techniques; Percutaneous Pinning for Fracture Repair; Minimally Invasive Plate Osteosynthesis Techniques for the Humerus; Minimally Invasive Plate Osteosynthesis Techniques for the Radius and Ulna; Minimally Invasive Osteosynthesis (MIO) Techniques of the Femur; Minimally Invasive Osteosynthesis Techniques for Articular Fractures; Unique Differences of Minimally Invasive Fracture Repair in the Feline; Perioperative Imaging in Minimally Invasive Osteosynthesis; Interlocking Nails for Minimally Invasive Osteosynthesis; Minimally Invasive Plate Osteosynthesis Techniques for Tibia and Fibula; Minimally Invasive Plate Osteosynthesis Techniques for Meta-bones; Minimally Invasive Osteosynthesis Techniques for Sacroiliac Luxation; and Minimally Invasive Plate Osteosynthesis Techniques for Arthrodesis.