In this issue of Physician Assistant Clinics, guest editor and emergency medicine physician assistant J. Randy Howell brings his considerable expertise to the topic of Medicine Outside Four Walls. Wilderness and austere medical practice addresses many aspects of this challenging field: recreational medicine (whitewater boating, skiing, rock climbing, backpacking), expedition medicine, global health, prehospital medicine, military medicine, and disaster medicine. In this issue, top experts discuss the unique and varied presentations, diagnostics, training, and treatment options in low resource and austere environments. Contains 16 relevant, practice-oriented topics including medicine from a chopper: search and rescue; medicine in uniform: military medicine; medicine with a checkered flag: race/event medical coverage; medicine on the river: whitewater and river medicine; wilderness medicine access: developing wilderness medicine training and practice opportunities; and more. Provides in-depth clinical reviews on wilderness and austere medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.