In this issue of Orthopedic Clinics, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of Infections. Eleven top experts discuss key concepts relating to infections to guide effective decision making. Early diagnosis and treatment are key to success, and in order to address an infection, the medical care team needs to address four fundamental questions: where is it, what is it, how severe is it, and how to treat it. The articles outlined in this issue will help physicians better understand common pathogens, identify signs of infection, and ultimately answer these fundamental questions in order to improve patient outcomes. Contains 14 relevant, practice-oriented topics including current concepts on the clinical and economic impact of periprosthetic joint infections; the state of local antibiotic use in orthopaedic trauma; navigating the enigma of pediatric musculoskeletal infections: a race against time; the septic elbow joint; diagnosis and management of infected total ankle replacements; and more. Provides in-depth clinical reviews on infections, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.