Genetic programming is a method for getting a computer to solve a problem by telling it what needs to be done instead of how to do it. Koza, Bennett, Andre, and Keane present genetically evolved solutions to dozens of problems of design, optimal control, classification, system identification, function learning, and computational molecular biology. Among the solutions are 14 results competitive with human-produced results, including 10 rediscoveries of previously patented inventions. Researchers in artificial intelligence, machine learning, evolutionary computation, and genetic algorithms will find this an essential reference to the most recent and most important results in the rapidly growing field of genetic programming.