In this issue of Surgical Pathology Clinics, guest editor Dr. Rondell P. Graham brings his considerable expertise to the topic of Gastrointestinal Pathology. The first half of this issue answers questions from the general pathologist about what new technologies and techniques can confidently be incorporated into daily practice. The second half addresses longstanding riddles and recurring tests, making this issue an excellent resource for practicing pathologists facing new and continuing challenges in GI pathology. Contains 11 practice-oriented topics including artificial intelligence-enabled gastric cancer interpretations: are we there yet?; non-conventional dysplasia in inflammatory bowel disease; a practical approach to small round blue cell tumors involving the GI tract and abdomen infectious disease pathology of the GI tract: diagnosing the challenging cases; and more.  Provides in-depth clinical reviews on gastrointestinal pathology, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.