In this issue of Clinics in Laboratory Medicine, guest editors Drs. Christopher P. Holstege and Joshua D. King bring their considerable expertise to the topic of COVID-19 Molecular Testing and Clinical Correlates. Top experts in the field cover key topics such as point-of-care molecular assays for SARS-CoV-2; strategies for scaling up SARS-CoV-2 molecular testing capacity; cycle threshold values from SARS-CoV-2 PCR assays; and more. Contains 12 relevant, practice-oriented topics including analytic and clinical performance of major commercial SARS-CoV-2 PCR assays in the United States; isothermal assays for SARS-CoV-2 detection; rapid antigen assays for SARS-CoV-2; approaches to deployment of molecular testing for SARS-CoV-2 in resource-limited settings; and more.  Provides in-depth clinical reviews on COVID-19 molecular testing and clinical correlates, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.