This issue of the Surgical Oncology Clinics of North America is devoted to Practical Radiation Oncology and is Guest Edited by Dr. Christopher Willett. Articles in this issue include: Radiotherapy After Mastectomy; Contemporary Radiotherapy in Head and Neck Cancer; Image Guided Brachytherapy: An Update for Gynecologic Surgeons; Radiation Therapy in the Current Management of Anal and Rectal Cancer; Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes; Contemporary Integration of Radiation Oncology with Surgery as Combined Modality Treatment; Chemoradiation Therapy: Localized Esophageal, Gastric, and Pancreatic Cancer; Stereotactic Body Radiotherapy for the Treatment of Primary and Metastatic Pulmonary Malignancies; Radiotherapy and Radiosurgery for Tumors of the Central Nervous System; Practical Radiation Oncology for Extremity Sarcomas; Radiation Therapy for Prostate Cancer; and Present and Future Innovations in Radiation Oncology.